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Connective Tissue and Joint Support By elevating IGF-1, MK-677 indirectly supports the repair of tendons, ligaments, and cartilage

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Those on certain medications should consult their physician

So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets

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Oral forms (capsules, sprays, or drops) are easier to administer