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In the past, it was used by manufacturers to give popcorn its buttery taste and in 2002 eight cases of irreversible lung disease were documented in people who had worked at a Missouri popcorn factory between 1992 and 2000

doi: 10.1016/S2468-2667(21)00102-X 5

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Interventions Varenicline 1 mg twice daily (titrated during the first week) or placebo for 12 weeks, with 14 weeks follow-up after treatment