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Lipid Metabolism & 3-AR Mechanism Heffernan et al., Endocrinology (2001) Heffernan and colleagues investigated the lipolytic effects of chronic AOD-9604 treatment using two complementary mouse models: diet-induced obese C57BL/6J mice and beta3 adrenergic receptor (3-AR) knockout mice

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When the function of mitochondria declines, the ability to remove reactive oxygen species (ROS) decreases, resulting in a decrease of mitochondrial membrane potential (MMP) and DNA copy number of mitochondria (mtDNA copy number) mutations, thus causing cell apoptosis [13, 14]

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