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All these findings suggest that both the plant and its active compound possess broad antiparasitic potential

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Conversely, based on atomic absorption spectroscopy data on depolarization-induced release of copper from nerve endings, one can estimate an activity-dependent enhancement of copper in the synaptic cleft, in the range of 100-250 M [225], depending on the cleft size and volume taken

Methods A comprehensive literature search was conducted across PubMed, Web of Science, Embase, and the Cochrane Library for articles published from inception to August 2025