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Alshial EE, Abdulghaney MI, Wadan AS, et al

Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Jollow et al., 1973)

PMID: 14722139 DOI: 10.1001/jama.291.2.182-a Shih ML et al (1994): Metabolite pharmacokinetics of soman, sarin and GF in rats and biological monitoring of exposure to toxic organophosphorus agents