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Description

DJ-1 functions as a bona fide negative modulator of ferroptosis by sustaining S-adenosyl homocysteine hydrolase activity through altering its interaction with the negative regulator adenosylhomocysteinase like protein 1, thereby maintaining the transsulfuration pathway-mediated biosynthesis of homocysteine and subsequent GSH synthesis (157)

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Dickinson, D.A., et al., Cytoprotection against oxidative stress and the regulation of glutathione synthesis

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PMID 26110130

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