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Bioavailability refers to the proportion of a substance that enters the circulation when introduced into the body and is so able to have an active effect

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Excipients such as sorbitol, mannitol (sugar alcohols), lactose (in those with intolerance), and various binding agents or fillers may contribute to gastrointestinal symptoms

In a longitudinal study of patients with bronchiectasis, NE activity in sputum was significantly associated with airway bacterial load, risk of bronchiectasis exacerbations, pulmonary functional decline, and risk of hospitalization (112)

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