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When DOX was administered alone, only an 11% survival rate was observed as compared to a 62% survival rate observed when DOX was combined with SFN

In conditions of nutrient depletion, ULK1 is activated, which leads to phosphorylation of the components of the Class III PI3K vacuolar protein sorting 34 (VPS34) protein complex, resulting in the formation of autophagosome and promoting the autophagy flux [255]

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