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Table 2 Preclinical and clinical evidence on the antidepressant effects of Ginkgo biloba and its combinations: mechanisms and efficacy

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81: 213 Hansbrough J, Wedner JH, Chaplin D

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Together, these data support a model in which adoptively transferred splenocytes from aged mice initiate a systemic inflammatory cascade, which in turn activates and expands endogenous tissue-resident macrophages, leading to sustained tissue functional impairment