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FOXO4-DRIs capacity to clear senescent cells also shows promise in improving chemotherapy outcomes when treating cancer, by reducing therapy-induced cellular damage

In addition, invertebrates models are genetically tractable and offer a powerful approach to dissect the core genetic underpinnings of SCZ, while vertebrate models, especially mammals, with their more complex nervous systems and behavioral repertoire, provide a closer approximation of the human condition to study SCZ-related traits

& Hajishengallis, G

This system is highly expressed in astrocytes, the main GSH synthesizing cells in the brain, and is regulated by various factors, including oxidative stress and inflammatory cytokines Once synthesized, GSH can be metabolized by various enzymes, including glutathione S-transferases (GSTs), which conjugate GSH with xenobiotics and endogenous electrophiles for elimination, and gamma-glutamyl transpeptidase (GGT), which cleaves GSH into its constituent amino acids and generates extracellular glutamate, a major neurotransmitter in the brain

Gender-specific effect of urate on white matter integrity in Parkinsons disease

Because animal reproduction studies may not always be predictive of human responses, this drug should be used during pregnancy only if clearly needed