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Generating sufficient safety evidence would require large-scale clinical trials involving thousands of participants

Yes, combining the two can be beneficial

Effects of Tirzepatide on Lipid Profile: A Systematic Review and Meta-Analysis

That said, the animal research is genuinely interesting and points toward several areas worth continued investigation

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso