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e , f ) Representative Trkb Penk-KO Gsto2 -shRNA injected striatal section immunostained for GSTO2 to show the knockdown effect of the shRNA in transduced iSPN + cells ( e , highlights the yellow area presented in the overview in f )

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2.4 Gene Expression Modulation: Genomic studies (e.g., Pickart et al., 2012) reveal GHK-Cu resets over 4,000 genes to a youthful state, upregulating repair genes and downregulating inflammatory ones, a unique epigenetic effect