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Furthermore, heterogeneity in tumour stage (or indeed, location), patient populations and treatment dose and duration is likely to confound reported response data, particularly given the links between changes in oxidative metabolism and metastatic spread 84,85,86,87

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Thus, at present GSH synthesis in both of these organisms is disputable and a thorough investigation using chemically defined medium and expression studies is required to establish the status of GSH system in Lb

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