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Inflammatory Bowel Disease: Clinical Aspects 189 Differential Diagnosis Figure 15.3

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First, we selected candidate residues for the potential glutathione activator site and the glutathione-scaffold site

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Synthesis, biological evaluation and molecular modeling study of 2-(1, 3, 4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors