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Recently (2024) it was demonstrated that the ability of metformin to suppress food intake is due to the induction of the production of the anorexigenic metabolite, N-lactoyl-phenylalanine (Lac-Phe)

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So basically, your large intestine is specifically designed to house trillions of microbes, but your small intestine isnt

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The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline (semaglutide injection 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide injection 0.7%, placebo 0.4%)

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