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Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors

Those most commonly affected include people over 50 as the ability to absorb B12 from food naturally declines with age as well as vegetarians and vegans, those with pernicious anaemia, anyone who has undergone gastrointestinal surgery, and those living with digestive conditions such as Crohn's disease or coeliac disease

Appetite changes often occur early in treatment

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