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Robinson TE, Berridge KC
Redox clamp model for study of extracellular thiols and disulfides in redox signaling
The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]
an ton s dng - Hng dn s dng: + Ngy 2 vin, ung 1 ln hoc chia 1 vin sng 1 vin ti
HEK293T cells were received as a gift from Professor Jincai Luo (Peking University, China)