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Biomarker development is essential for identifying atrisk populations prior to the onset of overt motor symptoms [235, 236]

[DOI] [PubMed] [Google Scholar] 96.Sugui J.A., Pardo J., Chang Y.C., Zarember K.A., Nardone G., Galvez E.M., Mullbacher A., Gallin J.I., Simon M.M., Kwon-Chung K.J

Despite that mitochondria are exposed to the generation of oxidant species, the existence of an efficient antioxidant defense system, of which mGSH is a critical component, prevents or repairs oxidative damage generated during normal aerobic metabolism ( MITOCHONDRIAL ROS GENERATION AND DEFENSE Reactive oxygen species can be generated in several intracellular sites, including cytosol, peroxisomes, plasma membrane, and ER

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Htt R6/2 (Huntington): protein aggregation model, motor and cognitive decline