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Kasai H, Fukuda M, Watanabe S, Hayashi-Takagi A and Noguchi (2010) J Structural dynamics of dendritic spines in memory and cognition

Role of Vitamin B6 Status on Antioxidant Defenses, Glutathione, and Related Enzyme Activities in Mice with Homocysteine-Induced Oxidative Stress

Therefore, FOXO4-DRI's targeted mechanism suggests a potential research outcome by facilitating the removal of senescent cells, which may contribute to tissue rejuvenation and improved organ function while still preserving the critical antioxidant defenses mediated by FOXO4

Its also why the two were combined in CagriSemathe idea being that together, they cover more ground than either one alone

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Mangino G, Famiglietti M, Capone C, Veroni C, Percario ZA, Leone S, Fiorucci G, Llf S, Romeo G, Agresti C, Persichini T, Geyer M, Affabris E