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Mitochondria transfer restores fibroblasts-like synoviocytes (FLS) plasticity in LPS-induced, in vitro synovitis model

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A pronounced reduction in melanin levels was observed in the VH032-Azi3 + Alk-TIn + SA cream group as a consequence of TYR degradation, which showed a 2.8-fold decrease than the blank cream treatment group, a 2.2-fold decrease than the epi-VH032-Azi3 + Alk-TIn + SA cream treatment group, and a 1.3-fold decrease than the DeTYR-3 group