Major drug Interactions: Decongestants Local anesthetics w/ sympathomimetics Antihypertensives CNS depressants Drugs metabolized by P450-2D6 Concomitant use of MAOI's can cause potentially fatal hyperpyretic crisis & seizures History: The therapeutic & commercial success of phenothiazine antipsychotics initiated a large scale search for more effective antipsychotics during the early 1950's
Proteomic alterations and novel markers of neurotoxic reactive astrocytes in human induced pluripotent stem cell models
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Results OTS964 blocks the spliceosome in a B-B act intermediate with integrated NTR and unbound NTC Previously, we showed that CDK11 inhibition by OTS964 blocks spliceosome during B to B act transition, in a B-like intermediate 8
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