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230 They tried a nonionic surfactant PS-80 coating among their formulations and proved drug delivery across BBB could be promoted by interacting with lipoprotein receptors

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Indeed, GH-replacement therapy, as well as treatment with rhIGF-1, increased serum calcitriol levels in GH-deficient patients [145, 146]

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Some protocols also explore combining IGF-1 optimization with pathways involving follistatin and myostatin inhibition, though this area continues to evolve in research settings