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Currently, there are no firm recommendations about its use in treating IBD in pregnant women, but given the availability of more targeted anti-integrins, this agent is not commonly used for Crohn disease
An argument can therefore be made that the real ALD is actually the adrenomyeloneuropathic form, with the more aggressive cerebral ALD of young boys driven by a superimposed autoimmune inflammation that is secondary to the myelin lipid derangement
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In silico prediction of chemical Ames mutagenicity
The model is then combined with a comprehensive glutathione metabolism model, facilitating the simulation of quinone redox cycling, and adduct-induced GSH depletion
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