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IGF-1 LR3 is an engineered analog of native IGF-1, not the natural hormone

One wrong twist, one heavy lift, or sometimes nothing at all, and suddenly you're dealing with searing sciatic pain, numbness, or weakness that makes simple tasks feel monumental

Rocha P, Zhang J, Laza-Briviesca R, Cruz-Bermudez A, Bota-Rabassedas N, Sanchez-Espiridon B, Yoshimura K, Behrens C, Lu W, Tang X, Pataer A, Parra ER, Haymaker C, Fujimoto J, Swisher SG , Heymach JV, Gibbons DL, Lee JJ, Sepesi B, Cascone T, Solis LM, Provencio M, Wistuba II, Kadara H

Annu Rev Immunol (2018) 36:10325

You do not necessarily have to choose one over the other, as they support the body in complementary ways, but identifying your primary "friction points" can help you prioritize

It often determines which tissue gets the strongest effect