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Pharmacokinetic studies in rats demonstrated an oral bioavailability of 38.4%, with a mean Cmax of 2,252 ng/mL and terminal elimination half-lives of 3.80 1.10 hours (IV) and 6.90 1.20 hours (oral) (Awosemo et al., 2021)

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Methylcobalamin has some metabolic and therapeutic in applications not shared by the other forms of vitamin B12

However, several groups are at high risk of deficiency and may benefit significantly from regular injections or supplementation

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Isolated pyridoxine deficiency is rare