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However, no controlled study has examined this combination in any species

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An intramuscular injection (commonly 1,000 mcg , given in the upper arm, hip or thigh) sidesteps the gut entirely and delivers a near-complete dose into circulation within minutes

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Factors including joint size, disease severity, and individual patient characteristics may influence optimal protocols

Capsules are often discussed for convenience and digestive support, while injections are often reviewed for more direct delivery