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Notably, senescence-associated -galactosidase (SA--gal) activity, detectable histochemically at pH 6.0 (compared to its optimal pH of 4.0 in non-senescent cells), remains the most widely used biomarker

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Nagra RM, Becher B, Tourtellotte WW, Antel JP, Gold D, Paladino T et al

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Gastrointestinal side effects may complicate disease assessment in conditions like inflammatory bowel disease, and drug interactions with immunosuppressants should be considered

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