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Tirzepatide mimics the action of natural incretin hormones while providing extended receptor activation, making it a novel subject for models involving type 2 diabetes , obesity , and metabolic syndrome

Controlled human data is more limited, which is why it remains a research-use compound in most jurisdictions the gap between animal and human evidence is its most-cited limitation

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LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a Phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial

Aboul-Ella, H., Gohar, A., Ali, A

Unlike other GH secretagogues, ipamorelin very surprisingly does not induce a significant increase in adrenocorticotropic hormone (ACTH) or cortisol