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Furthermore, multiple studies have provided evidence for dose-dependent exposure effects on gray matter integrity within the insula [18, 85] and vmPFC [19, 22, 86] as well as within the lateral PFC [14, 20] and cerebellum [23]

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To encompass cigarette use as well as use of other tobacco or nicotine products, we use the term tobacco and nicotine dependence treatment. The main components of this treatment are behavioral therapies and medications

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