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Persistent or worsening symptoms despite supplementation warrant medical review

Buffered NAD+ ships with a pH stabilizer (most commonly Tris) that brings the reconstituted solution closer to physiological pH (~7-8.5), while unbuffered NAD+ reconstitutes acidic (~pH 3-4) and is more often associated with injection-site stinging

This makes it especially useful in laboratories that need a stable, uncontaminated solution for repeated use in various experiments and procedures

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The peptide was initially manufactured for veterinary purposes in the early 2010s, but was subsequently banned for use in horse racing [16, 17]

Dehydration worsens nausea, and the vomiting and diarrhea that some researchers experience can create a dehydration cycle that amplifies symptoms