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[11] [12] There is a potential risk of pancreatitis

doi:10.2174/157015909787602788 Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, ONeil GN, BG-12 Phase IIb Study Investigators (2008) Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

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Further studies revealed that Nrf2 knockdown had an activating effect on STAT3, suggesting that Nrf2 and STAT3 co-regulate SLC7A11 to reduce ferroptosis and protect against IIR-ALI

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Administration Typical delivery methods are subcutaneous or intramuscular injection, oral formulations, and nasal sprays