Due to the presence of several hydroxyl groups and, consequently, good metal-chelating properties, flavonoids have been studied for their protective effects on neurological disorders
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This effect involves upregulation of integrin receptors, particularly alpha5beta1 and alpha2beta1, which mediate keratinocyte attachment to provisional matrix proteins including fibronectin and collagen
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BDNF is widely present in the brain and participates in the growth, differentiation, and survival of neuronal cells, and its expression level is closely related to memory function [41, 42]
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