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Zhou npj Imaging .2025;[Epub] CrossRef Identification of hub gene for the pathogenic mechanism and diagnosis of MASLD by enhanced bioinformatics analysis and machine learning Hong Lu, Ziyong Mao, Mengyao Zheng, Min Zhang, Heqing Huang, Yiling Chen, Long Lv, Zutao Chen, Akif Altnbas, PLOS One .2025

Leukemia 19 , 17511759 (2005)

TFAM is almost exclusively present in a DNA-bound form (Takamatsu et al., 2002), and degradation of TFAM proteins by mitochondrial matrix proteases directly affects mtDNA copy number (Matsushima et al., 2010)

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While some studies have not found a similar effect in Hepatitis B surface antigen (HBsAg)-seropositive patients regarding ALT levels, other research indicates an increased risk of cirrhosis in HBV carriers who smoke 20 or more cigarettes per day, an effect that is particularly pronounced when combined with habitual alcohol consumption [85, 86]