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Lipolytic-fragment signalling (AOD-9604): a modified fragment of human growth hormone (hGH 176-191) studied in isolated metabolic-signalling models

All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)

It is an important hormone that is produced in pregnant women until on average the 11th week of pregnancy

Deficiencies may manifest as neurological symptoms, including numbness, tingling, and cognitive disturbances

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The selectivity for beta-3 receptors explains the favorable safety profile compared to non-selective beta agonists that cause cardiovascular stimulation and other systemic effects