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A meta-analysis of GSH has been done in patients with BPAD and found a significant increase in GSH in the anterior cingulate cortex in patients as compared with healthy controls (Das et al

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KLOW is interesting because it isnt built around one dominant hypothesis

Oxygen and glucose deprivation lead to the stabilization and/or upregulation of microglial HIF-1 (Xu et al., 2023), which, in turn, results in increased autophagy, TLR4, IL-1, and IL-18 expression, and NLR family pyrin domain containing 3 (NLRP3) inflammasome formation, suggesting HIF-1 contributes to the proinflammatory phenotype of microglia after a stroke event (Guo et al., 2009

doi:10.1002/prot.24208