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This reduction in butyrate may contribute to the inhibition of intestinal epithelial tight junction protein secretion[101 ] (Fig

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J Med Chem 44:42684276

The IL-6 transmits inflammatory-related information via IL-6 receptor and glycoprotein 130 (gp 130) that makes a specific receptor complex that causes gp130-associated Janus kinases (Jak) to become activated, and results in the phosphorylation of tyrosine residues within the cytoplasmic part of gp130 serve as binding sites for the transcription factor STAT3, JAKs and phosphorylated STAT3-dimers phosphorylate these translocate into the nucleus to induce STAT-specific gene expression