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Yes, there's a strong genetic component

If youre feeling constantly fatigued, struggling with focus, or simply want to support your overall well-being, a Vitamin B12 shot could be the perfect solution

Peer review Peer review information Nature Reviews Neuroscience thanks Caroline Trumpff and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Iron regulatory proteins (IRPs), bind to iron-responsive elements (IREs) in the 5 untranslated region (UTR) of mRNAs encoding ferritin and FPN1 to inhibit their translation, while binding to IREs in the 3 UTR of TfR1 and DMT1 mRNAs to stabilize these transcripts, thereby adjusting iron storage, export, and uptake (41, 58)

Here are a couple of tips for choosing a great B12 supplement: Find a supplement which contains methylcobalamin: as it is a naturally occurring form of B12, it can be absorbed more easily than a synthetic form which is not as easily recognised by the body