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High-dose oral supplements and intravenous B12 are used to treat severe deficiency cases because these methods help people who struggle with gut absorption issues

Weight fluctuates daily due to water retention, food volume, and hormonal cycles, so weekly averages provide better data than daily numbers

PMID 11470726

Yes, if you are willing to prepare

However, they are not a standalone solution for weight loss

This mechanistic distinction means the compound could theoretically be combined with appetite-suppressing peptides for a protocol that simultaneously reduces energy intake (GLP-1) and restores adipocyte energy expenditure (NNMT inhibition) though this remains purely theoretical without published combination data