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If one edge of the patch becomes loose, use tape or a sticky adhesive film to secure the loose edge

This makes it useful for studying mechanisms involved in satiety, food intake, and downstream metabolic effects in both preclinical models and clinical research settings

Downregulation of HIF-1 significantly reduces the number of IL-10 secreting B cells, exacerbating collagen-induced arthritis and experimental autoimmune encephalomyelitis (EAE) (89)

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