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Early exposure increases the risk of long-term substance dependence

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For example, a study looking at self-reported smoking history among patients diagnosed with lung cancer in registries from the University of Texas Southwestern Medical Center, Parkland Hospital, and Vanderbilt University showed that the proportion of cases in patients who have never smoked almost doubled from 8.0% in 1990-1995 to 14.9% in 2011-2013

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