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Available at: Jung SY et al (2011): Short-acting nifedipine and risk of stroke in elderly hypertensive patients

The reduction in total drug delivered to the systemic circulation is referred to as the First Pass Effect - reflecting the loss of drug via its first pass thru the GI tissues & liver before it reaches the systemic circulation

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doi: 10.1371/journal.pone.0212689 57 LiuP.LiuZ.WangJ.WangJ.GaoM.ZhangY.et al

Many athletes opt for glutathione injections or IVs to aid in achieving these objectives