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These include direct NLRP3 inhibitors (e.g., CY-09, MCC950, OLT1177/dapansutrile, oridonin, INF39, tranilast), blockade of pyroptosis or downstream effectors (e.g., disulfiram, dimethyl fumarate, maresin-1), and interference with adaptor or cytokine pathways such as ASC, NEK7, caspase-1, and IL-1 (e.g., lycorine, entrectinib, VX-765/X-740, canakinumab)

Furthermore, the R72 variant was shown to harbour increased AMPK-sensitivity as measured by p53-Ser15 phosphorylation in glucose-deprived cancer cell lines and in liver and pancreas of mice treated with the AMPK activator AICAR 39

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