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doi: 10.1155/2020/8249729 136 KawasakiT.KawaiT

This creates a self-targeting effect in the tissue that needs intervention most

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When GHRP-2 binds to GHSR-1a in the hypothalamus, it is theorized to trigger a signal transduction cascade that could lead to increased production of the hunger-inducing neuropeptide, Neuropeptide Y (NPY), and Agouti-related peptide (AgRP), both of which are believed to play significant roles in energy homeostasis and appetite regulation

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The animals were then deeply anesthetized with 3% isoflurane and 50 mg/kg of ketamine followed by a laminectomy at lumbar level L2-L3, corresponding to the sacrocaudal spinal cord