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Studies have demonstrated that mutations in the NOD2 gene are associated with susceptibility to Crohns disease and severe pneumonia, potentially due to lung immune imbalance caused by intestinal flora dysregulation (149, 150)

Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL , Assis DN, Ghonem NS

There may also have been problems with sample storage over long periods, especially for plasma homocysteine and vitamin analyses

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