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Higher NAD+ levels activate SIRT1, a master regulator of metabolism, mitochondrial biogenesis, and fat oxidation

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Antioxid Redox Signal 7:3241 Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I (2008) Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smokemediated oxidative stress in human lung epithelial cells

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In this study, we demonstrated that the glutathione metabolism pathway is highly enriched in ESCC cells compared with normal esophageal epithelial cells in an in vivo mouse model