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2: discrete generalized irregularity in the diameter of the blood vessels with mild atrophy of the optic disc, normal presentation of the choroidal blood vessels (normal reddish fundus background color)

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A recent study showed that the accumulation of UA in DNA-damaged tumors activates TAK1 and its downstream kinases, JNK, and AMPK, to phosphorylate ULK1 S555 and initiate autophagy [215](Fig

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