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Combined, these effects disrupt normal cyclic hormone patterns, change feedback to the hypothalamus and pituitary, and can result in irregular cycles, low sperm quality, or anovulation

Values in selected population of athletes

BUSTER version 2.10.2 Cambridge: Global Phasing Ltd, UK (2016)

(2016) Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia, Oncotarget , 7 , 14659-14672, doi: Njlsson, R., and Norgren, S

Generally very well-tolerated

R The clinical relevance for detoxification: Met/Met individuals have reduced capacity to methylate and inactivate catechol estrogens (2-OH and 4-OH estradiol)