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In stroke research, for example, models that incorporate hypertensive or diabetic phenotypes have demonstrated significantly altered responses to neuroprotective interventions compared to normotensive controls, underscoring the critical importance of patient-specific biological contexts [575]

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In terms of pathogenicity, distinct strains show obvious divergence in core virulence traits: for example, chromosome 7 trisomic strains present attenuated hyphal formation due to NRG1 overexpression, while euploid strains form robust hyphae with stronger tissue adhesion and invasion capabilities (Kakade et al., 2023)

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(2013) evaluated 800 mg/day of green tea extract (45% EGCG content) versus placebo for 4 months in women with symptomatic uterine fibroids