Cancer Res 76:43114315 Zhang H, Wang Y, Onuma A, He J, Wang H, Xia Y, Lal R, Cheng X, Kasumova G, Hu Z (2021) Neutrophils extracellular traps Inhibition improves PD-1 Blockade immunotherapy in colorectal cancer
Homocysteine metabolism gene polymorphisms (Mthfr c677t, mthfr a1298c, mtr a2756g and mtrr a66g) jointly elevate the risk of folate deficiency
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doi: 10.1172/JCI200524408
Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]
& van den Buuse, M