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Folic acid supplementation delays atherosclerotic lesion development by modulating MCP1 and VEGF DNA methylation levels in vivo and in vitro

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Recently, intermolecular contact formed by brazilein, identified as an oxidized form of brazilin (neoflavonoid), via copper chelation along with hydrophobic and hydrogen bonding in the catalytic core of tyrosinase was established to induce structural variations in the secondary structure of the protein 83

Thus, intracellular dehydration, which increases the MCHC, facilitates sickling